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In contrast, despite a significant reduction in plaque burden, DL-fed 3xTg females did not show a reduction in the number of either GFAP or IBA1-positive cells (Fig

doi:10.2174/157015909787602788 Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, ONeil GN, BG-12 Phase IIb Study Investigators (2008) Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

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The concurrent elevation of DNA, histones, and HMGB1 levels has been shown to induce coagulation dysfunction in sepsis models [115, 116]