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The main reason is public safety

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This program consisted of two phase 3, randomized, double-blind, placebo-controlled trials: one in adults not using positive airway pressure (PAP) therapy and another in adults using PAP therapy

Graphical abstract Similar content being viewed by others Background Incretin hormonesglucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)are secreted by the gastric mucosa to promote post-prandial insulin secretion

[10] [11] However, balance efficacy against gastrointestinal tolerability, as adverse effects may compromise adherence

Patients experiencing significant gastrointestinal symptoms should focus on tolerating their prescription medication before adding supplements