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Hyperinsulinaemia associated with abdominal obesity stimulates TG synthesis in the liver

However, a stimulatory response of GEP44 was observed only in the presence of Y1-R-specific antagonists (PD160170 or BIBO3304Fig

Nuclear factor erythroid 2-related factor 2 (Nrf2) as the key transcription factor playing an essential role in redox balance and depleted in COPD patients (Deshmukh et al., 2017), modulates the expression of approximately 100 genes functioning the state of redox, inducing the transcription of glutathione (GSH) (Osburn et al., 2006)