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Through these mechanisms, SIN helps to maintain the dynamic balance between M1 and M2 macrophages, reduces macrophage chemotaxis and secretion, and inhibits macrophage apoptosis, thereby exerting potent immunosuppressive effects (Figure 4)

Glutathione neutralizes a wide range of free radicals by either directly binding to them or blocking their uptake

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The findings are expected to provide a clue for developing treatments that can break through this plateau