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What began as a breakthrough in metabolic care has become an arms race of pharmacology and finance

52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA

They should only be used exactly as tested, approved, and prescribed

doi: 10.1056/NEJMoa0804748

Younger people (under 40) tend to lose weight faster, preserve muscle more easily, experience less loose skin, and achieve more dramatic before and after comparisons