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To date, no inhibitor specifically targeting the CPERS activity of CARS has been reported

Nature 2015;520:5762

Wellness is built on small, daily habits rather than occasional high-intensity efforts

Mechanistically, YAP/TAZ induce the expression of SLC7A11 in a TEAD-dependent manner, and sustain the protein stability, nuclear localization, and transcriptional activity of ATF4 which in turn cooperates to induce SLC7A11 expression