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It is worth noting that unlicensed medicines can be lawfully supplied in limited circumstances for example, as 'specials' manufactured to meet the specific clinical needs of an individual patient under a prescriber's direction

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In cerebral malaria, a double-blind trial has shown that the use of corticosteroids is associated with prolonged coma and with a higher incidence of gastrointestinal bleeding and pneumonia

Payers classify them under entirely different benefit categories: vaccines go to preventive care, therapeutic injections go to medical benefits

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