VTP-27999 0264 Laropiprant itself has no cholesterol
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VTP-27999 0264 Laropiprant itself has no cholesterolVTP 27999 is a highly potent and selective renin inhibitor (IC50 = 0. 47 nM). It exhibits >1000 selectivity for renin over >150 receptors, ion channels and enzymes. Renin is an asparyl protease that cleaves angiotensinogen into angiotension I in the plasma. It functions as a regulator of blood pressure and sodium homeostasis. In vitro, VTP 27999 increases renin immunoreactivity by 30%, it bind to acid activated, intact prorenin and promotes
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