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ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 AMG232 is an extremely potent

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ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 AMG232 is an extremely potentALW II 41 27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small molecule inhibitor ALW II 41 27 decreased both survival and proliferation of erlotinib resistant tumor cells and inhibited tumor growth in vivo. ALW II 41 27 was also effective in decreasing viability of cells with acquired resistance to the third generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of

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Description

AMG232 is an extremely potent MDM2 inhibitor (SPR KD = 0

This mechanism of action is unique among antiepileptic drugs

Formula: C18H20FN5O2

as well as an H1 receptor inverse agonist/antihistamine

Formula: C24H16O7

ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 AMG232 is an extremely potentALW II 41 27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small molecule inhibitor ALW II 41 27 decreased both survival and proliferation of erlotinib resistant tumor cells and inhibited tumor growth in vivo. ALW II 41 27 was also effective in decreasing viability of cells with acquired resistance to the third generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of

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