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[1] [4] Cognitive Function and Metabolic Health Brain function and metabolic health depend heavily on energy availability

The result is destruction of the myelin sheet, which hampers neural transduction and cause symptoms that include a loss of reflexes and balance and the loss of feeling in arms and legs [165]

Damaged mtDNA accumulation and fragmented mitochondria lead to increased production of ROS and activate apoptosis in the tubules (91)