p53(Phospho Ser378) Polyclonal Antibody, 50ul Drying & Desiccation The mitogen-activated protein kinase kinase

The mitogen-activated protein kinase kinase kinase 8 localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways

This gene encodes multiple protein isoforms that differ in their inhibitory activity

Two transcript variants| only one of them protein-coding| have been found for this gene

termed the retromer complex

|Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine| and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

p53(Phospho Ser378) Polyclonal Antibody, 50ul Drying & Desiccation The mitogen-activated protein kinase kinaseThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.