PF-670462 2HCl - CAS# 950912-80-8 0158 TAS-301 (1-10 μM) concentration-dependently inhibits
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PF-670462 2HCl - CAS# 950912-80-8 0158 TAS-301 (1-10 μM) concentration-dependently inhibitsPF 670462 2HCl, CAS No. 950912 80 8, is a potent inhibitor of the CK1 isoforms CK1 and CK1 (IC50 = 7. 7 and 14 nM, respectively). Inhibition of CKIepsilon yields a perturbation of oscillator function that forestalls light as a zeitgeber, and they demonstrate that pharmacological tools such as PF 670462 may yield valuable insight into clock function. Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating
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