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Alpha-MSH is considered to be a non-selective agonist of melanocortin receptors 1, 3, 4, and 5

Large population studies show that adults with lower carotenoid consumption tend to report shorter sleep duration, suggesting that antioxidant status may influence healthy sleep patterns.34 A smaller randomized trial tested 12mg of astaxanthin daily for eight weeks and found improvements in several sleep parameters, along with reduced perceived stress compared to placebo.4 The authors proposed that astaxanthins antioxidant and neuroprotective activity including its ability to cross the bloodbrain barrier could help stabilize oxidative stress in brain regions involved in regulating sleep and mood

Marty Makary and National Institutes of Health director Jay Bhattacharya

Prescribers should also consider whether the benefits of concurrent use outweigh the risks, and whether alternative treatment strategies might be more appropriate for the individual patient