K-Ras G12C-IN-3 Catalog No.:M8513-10 a tyrosine kinase inhibitor

a tyrosine kinase inhibitor

Nutlin-3 can block the MDMX–p53 interaction and induce the p53 pathway in retinoblastoma cells (Weri1) with IC50 of 0

It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity

Icaritin (0-64 µM

It inhibits PHD2 via binding to the 2OG binding site

K-Ras G12C-IN-3 Catalog No.:M8513-10 a tyrosine kinase inhibitorK Ras G12C IN 3 is a novel and irreversible inhibitor of mutant K ras G12C. IC50 value: Target: K ras G12C inhibitorFor more information, please see the following patent. Heterocyclic compounds as covalent inhibitors of G12C mutant K Ras protein useful for treating cancers, and preparation thereofBy Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925. Product information CAS Number: 1629268 19