VH 298 20046 Indisulam (E7070)

Indisulam (E7070)

4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13

InChi: InChI=1S/C15H22N2

Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N2CCN(CCCOC3=CC4=C(NC5=CC(Cl)=C(F)C=C5)N=CN=C4C=C3OC)CC2)C(C)(C)C)=CC=1

Skrepnik N

VH 298 20046 Indisulam (E7070)VH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85