MLN0905 - CAS# 1228960-69-7 medil Hydrochloride PMPA sodium

PMPA sodium

CAS Number: 2140807-17-4

(20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs

extending from maintenance of pancreatic β cell survival and proliferation to the induction of apoptosis in cancer cells

Chemical Name: 12-chloro-4-[(2S)-pyrrolidin-2-yl]-8-oxa-3

MLN0905 - CAS# 1228960-69-7 medil Hydrochloride PMPA sodiumMLN0905 is a potent, selective small molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. These data strongly suggest evaluating PLK1 inhibitors as DLBCL anticancer agents in the clinic. (source: Mol Cancer Ther; 11(9); 2045 53.) Product information CAS Number: