ISRIB 66057 is a functionalized IAP ligand

is a functionalized IAP ligand for PROTACs

which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene

and 50 mg/kg for 18 months (groups O

Smiles: CO[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H]1O

and inhibits migration and invasion

ISRIB 66057 is a functionalized IAP ligandISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2 (eIF2) phosphorylation with IC50 of 5 nM. Product information CAS Number: 548470 11 7 Molecular Weight: 451. 34 Formula: C22H24Cl2N2O4 Chemical Name: 2 (4 Chlorophenoxy) N [4 [[2 (4 chlorophenoxy)acetyl]amino]cyclohexyl]acetamide Smiles: O=C(COC1C=CC(Cl)=CC=1)NC1CCC(CC1)NC(=O)COC1C=CC(Cl)=CC=1 InChiKey: HJGMCDHQPXTGAV UHFFFAOYSA