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Further [insulin] dose reduction with higher doses of semaglutide would be very small.Daily basal insulin doses dropped by 11.7% at 4 weeks, 12.4% at 8 weeks, 9.8% at 20 weeks and 15.6% at 26 weeks for the semaglutide group compared with baseline

Semaglutide is an FDA-approved GLP-1 medication for individuals with obesity and type 2 diabetes mellitus when combined with a healthy diet and exercise

Two recently developed methods for visually presenting complex weight and health-risk information that encapsulate substantial amounts of clinical trial observations were recently developed that can potentially supplement and give new insights into conventional GLP-1R agonist scientific reports

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*Correspondence: Yilei Mao, [email protected]

Serial paraffin sections (2 m) were stained for tartrate-resistant acid phosphatase (TRAP) using a Leukocyte Acid Phosphatase Kit (Sigma) according to the manufacturers instructions