Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 50ul Culture Plate Inserts A frequent polymorphism in the

A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness

hepatocellular carcinoma

the Salvador-Warts-Hippo (SWH) pathway

The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt

The protein is made as a precursor that is autocatalytically cleaved| the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing

Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 50ul Culture Plate Inserts A frequent polymorphism in theAlpha chains of type IV collagen have a non collagenous domain (NC1) at their C terminus frequent interruptions of the G X Y repeats in the long central triple helical domain (which may cause flexibility in the triple helix) and a short N terminal triple helical 7S domain. Type IV collagen is the major structural component of glomerular basement membranes (GBM) forming a 'chicken wire' meshwork together with laminins proteoglycans and entactin