Nibrin Polyclonal Antibody, 100ul[BT-AP06020] Protein Research Transcriptional modulator activated by BMP

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase

Mutations in KRT10 are associated with epidermolytic hyperkeratosis

Based on sequence comparison

CCNF encodes a member of the cyclin family

The gene is located in a cluster of S100 genes on chromosome 1

Nibrin Polyclonal Antibody, 100ul[BT-AP06020] Protein Research Transcriptional modulator activated by BMPMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.