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PMID: 40706741 Clin Pharmacol Ther Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter-Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal)

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Patients with specific FTO and MC4R genetic patterns may experience appetite suppression more rapidly, while those with different GIPR variants might have slower initial responses

doi: 10.1038/s41586-020-2668-z 38 KarimABajboujKShafarinJQaisarRHallACHamadM

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While isolated case reports of atrial fibrillation and acute coronary syndrome exist in post-marketing surveillance, establishing causality is challenging, as the patient population using these medications often has multiple cardiovascular risk factors independent of treatment