Phospho-APC (S2054) Polyclonal Antibody, 100ul Cell Function Analysis TMEM145 (transmembrane protein 145) is

TMEM145 (transmembrane protein 145) is a 493 amino acid protein encoded by a gene mapping to human chromosome 19

The protein encoded by this gene is an inner protein of the kinetochore

and it appears to regulate HER2

it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul

when overexpressed

Phospho-APC (S2054) Polyclonal Antibody, 100ul Cell Function Analysis TMEM145 (transmembrane protein 145) isAPC encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre malignant disease that usually progresses to malignancy. Disease associated mutations tend to be clustered in a small region designated the