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(+)-Apogossypol - CAS# 66389-74-0 or 1 Smiles: CCCCCCCCCC1=CC=C(C=C1)OCCO

(+)-Apogossypol - CAS# 66389-74-0 or 1 Smiles: CCCCCCCCCC1=CC=C(C=C1)OCCO

Name: (+)-Apogossypol - CAS# 66389-74-0 or 1 Smiles: CCCCCCCCCC1=CC=C(C=C1)OCCO
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(+)-Apogossypol - CAS# 66389-74-0 or 1 Smiles: CCCCCCCCCC1=CC=C(C=C1)OCCO(+) Apogossypol is a pan BCL 2 antagonist. (+) Apogossypol binds to Mcl 1, Bcl 2 and Bcl xL with EC50s of 2. 6, 2. 8 and 3. 69 M, respectively. Product information CAS Number: 66389 74 0 Molecular Weight: 462. 53 Formula: C28H30O6 Synonym: NSC736630 Apogossypol Chemical Name: 3,3' dimethyl 5,5' bis(propan 2 yl) [2,2' binaphthalene] 1,1',6,6',7,7' hexol Smiles: CC1=CC2=C(C(C)C)C(O)=C(O)C=C2C(O)=C1C1=C(O)C2=CC(O)=C(O)C(C(C)C)=C2C=C1C InChiKey:

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Description

Smiles: CCCCCCCCCC1=CC=C(C=C1)OCCO

In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold

SKF 104864A

306(5705):2257-60

20-lyase and 17α-hydroxylase with IC50 of 27 and 30 nM respectively

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