Rat Growth/Differentiation Factor 11, GDF11 ELISA Kit, 96T DNA/RNA Isolation & Purification BPTI/Kunitz inhibitor and E2 domains

BPTI/Kunitz inhibitor and E2 domains in the middle region

Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT)

PubMed: 15805301)

This gene encodes a protein with an N-terminal filamin-binding domain| a central proline-rich domain| and| multiple C-terminal LIM domains

Present mainly in the mitochondrial compartment of peripheral tissues

Rat Growth/Differentiation Factor 11, GDF11 ELISA Kit, 96T DNA/RNA Isolation & Purification BPTI/Kunitz inhibitor and E2 domainsSecreted signal that acts globally to specify positional identity along the anterior posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type 2, ACVR2A and ACVR2B, and activin receptors type 1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.