IKK alpha/beta(Phospho Ser176/177) Polyclonal Antibody, 100ul Endonucleases & Exonucleases Alternative splicing has been observed

Alternative splicing has been observed for this locus and two variants are described

The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells

and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex

and pharmacologic properties

Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation

IKK alpha/beta(Phospho Ser176/177) Polyclonal Antibody, 100ul Endonucleases & Exonucleases Alternative splicing has been observedThis gene encodes a member of the serine threonine protein kinase family. The encoded protein a component of a cytokine activated protein complex that is an inhibitor of the essential transcription factor NF kappa B complex phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway thereby activating the transcription factor.