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Medications known as GLP-1 agonists, including exenatide, liraglutide, and semaglutide, activate the GLP1R, effectively lowering blood sugar levels and facilitating weight loss in individuals with type 2 diabetes

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Purpose-built for physicians Oral GLP-1 reduces body weight, HbA1c for adults with obesity plus type 2 diabetes Key takeaways: All doses of orforglipron conferred greater decreases in weight and HbA1c compared with placebo