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10.1016/j.ejphar.2015.12.010 304

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Data availability The authors declare that all data supporting this studys findings are included in the article

30 For every batch of finished product, thousands of gallons of solvent are often discarded, making the process vulnerable to raw material price volatility and environmental regulations

Compared with conventional two-dimensional culture systems and many animal models, they provide a more human-relevant and structurally complex framework for investigating disease mechanisms and preclinical drug effects