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Following the absorption of sugar, GLP-1 and GIP secreted by cells of the intestine make it possible to very significantly increase the production of insulin by the pancreas, at levels much higher than those that are produced simply in response to the presence of sugar in the blood (Figure 1)

Some providers recommend an even more conservative approach for people who are particularly sensitive

Last reviewed 2026-07-27 NAMED SAFETY SIGNALS In SURMOUNT-1, reported by 24.6% (5 mg), 33.3% (10 mg) and 31.0% (15 mg) versus 9.5% on placebo

Ketosis , which can occur during significant weight loss or reduced carbohydrate intake, may also produce a characteristic fruity or acetone-like breath odour

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