PCBP2 Polyclonal Antibody, 100ul Vacuum Aspirator tissue specificity:Brain specific mainly in

tissue specificity:Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum

Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes

mediating their interaction

It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form

PCBP2 Polyclonal Antibody, 100ul Vacuum Aspirator tissue specificity:Brain specific mainly inThe protein encoded by this gene appears to be multifunctional. Along with PCBP 1 and hnRNPK, it is one of the major cellular poly(rC) binding proteins. The encoded protein contains three K homologous (KH) domains which may be involved in RNA binding. Together with PCBP 1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence specific interaction with stem loop IV of the IRES, promoting poliovirus RNA replication