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Intravenous (IV) administration of glutathione, on the other hand, bypasses the digestive system entirely, allowing for immediate and higher levels of glutathione in the bloodstream

In particular, proximal tubular epithelial cells express CYP27B1, which converts circulating 25-hydroxyvitamin D [25(OH)D] into its biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D]

& Gracely, R

J., Melnyk, S., Jernigan, S., Cleves, M

Naunyn Schmiedebergs Arch Pharmacol 385(1):6979

Ongoing dosing is typically required for biologics, which are usually administered via injection, although the frequency of administration differs by agent (Gooderham et al