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Matek D et al

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This mechanism of action led to the initial approval of GLP-1 RAs to manage type 2 diabetes

PYY can also be fused with active fragments of other hormones, such as GLP-1 and glucagon, to develop dual or triple target agonists

A Waters 2777c UPLC system (Waters, USA) coupled with a Q Exactive HF high-resolution mass spectrometer (Thermo Fisher Scientific) was utilized for the isolation and identification of metabolites