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Treatments were vehicle (V), CagriSema (CS, 2 + 2 nmol/kg), and calorie-restricted to match the weight of the CS rats (weight matched, WM)

Aetna Medicare Advantage excludes weight-loss use (CV indication coverable

Researchers should distinguish between chemical stability, experimental suitability, and biological interpretation

Funding This research was supported by the University of Surrey/Braithwaites Foundation and the Wellcome Trust (209099/Z/17/Z) to JS and National Institutes of Health (EY019022, HL114161, and HD088829) to MF

They exert direct positive impacts on the coronary vascular endothelium, such as oxidative stress reduction and increase in nitric oxide, which at least partially account for their antihypertensive and antiatherosclerotic properties (39)