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Ursodeoxycholic acid alters bile composition and reduces cholesterol crystal precipitation, a mechanism proven to lower new stone formation by up to 50% in rapid weight loss populations

GSTs gene polymorphisms and correlation to diseases GSTs are representedand expressed with unique patterns in each organin the human genome by multiple genes that are located in class-specific clusters on different chromosomes 31,32,33

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1b and Supplementary Table 2)

The pivotal phase II trial (MGL-3196-05, n = 125) randomized patients with biopsy-proven MASH to receive either 80 mg of resmetirom or a placebo for 36 weeks [26]