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Inhibiting IDO1 activity can promote glycolysis and lactate production in astrocytes, thereby improving the energy metabolism state of neurons

These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics, acting as incretin mimetics to target G-proteincoupled receptors like GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon

Gastroparesis by itself slows or altogether stops food from moving from the stomach into the small intestine despite there not being any blockage