Rat Mothers Against Decapentaplegic Homolog 4, SMAD4 ELISA Kit, 96T sgRNA Oligos It plays a central role

It plays a central role in sexual differentiation and androgen physiology

Multiple alternatively spliced transcript variants have been observed

The protein acts at a stage in exocytosis that follows ATP-dependent priming

At the plasma membrane

It is also amplified in solid tumor cell lines

Rat Mothers Against Decapentaplegic Homolog 4, SMAD4 ELISA Kit, 96T sgRNA Oligos It plays a central roleCommon SMAD (co SMAD) is the coactivator and mediator of signal transduction by TGF beta (transforming growth factor). Component of the heterotrimeric SMAD2 SMAD3 SMAD4 complex that forms in the nucleus and is required for the TGF mediated signaling. Promotes binding of the SMAD2 SMAD4 FAST 1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3 SMAD4 JUN FOS