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It's a hormone your own body makes

Samaridou, E., Heyes, J

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Pernicious Anemia Treatment Guidelines Treating pernicious anemia with high-dose B12 shots is not only 100% safe but also very potent

They often bring HbA1c levels down by between 0.5 to 1%, although the actual decrease varies from person to person depending largely on their blood sugar at diagnosis and other medications they may be taking

However, patients with pre-existing glutathione deficiency, malnutrition, liver compromise, or genetic variations affecting detoxification enzymes may experience greater depletion impact and warrant more cautious use or provider oversight