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Zhang et al., Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering MiR-30b-3p

T.HashimotoA

Gregor MF, Hotamisligil GS

The nucleophilic attack of the hydroxyl group of Thr-381 against the 5-carbonyl carbon of the -glutamyl moiety is facilitated by the -amino group of the same residue, which acts as a general acidbase catalyst generally found in the Ntn-hydrolase superfamily (Figure 5A)