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This concept is particularly relevant for peptides that engage widely expressed GPCRs, where early development efforts may have failed due to non-selective activation

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By modifying the peptide structure, pharmaceutical companies extended the half-life to days or weeks, allowing once-weekly injections to maintain therapeutic levels

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Therefore this Frontiers in Plant Science Research Topic aims to address the following major issues related to the interplay between NO signalling, ROS and the antioxidant system in plants: o Common targets and receptors (e.g

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