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Acidification in the microenvironment plays an immunosuppressive role and mediates the protonation of drugs, affecting their cell permeability ( 2.4 Association between increased glycolysis with clinical response and survival rates in ALs Despite the strong evidence that glycolytic metabolism can promote chemoresistance in primary leukemic cells from non-responders and/or multiresistant cell lines, recent advances in metabolomics platforms have allowed further investigation into tumor metabolism at the systemic level in patients with acute leukemia (Ye et al., 2018)

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Lifestyle changes can include increased physical activity, meditation, or even incorporating new routines that allow you to have consistently better sleep