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Dietary adjustments, probiotics and prebiotics use, and fecal microbiota transplantation might exert therapeutic effects on OA by inhibiting cartilage catabolism or apoptosis [144,145,146,147]

Since our sensor reports cellular energy state, the major activator of AMPK, future research should focus on exploring links between Q10 and the AMPK signaling pathway, which is known to trigger antioxidative defense enzymes

Esworthy RS, Doan K, Doroshow JH, Chu FF (July 1994)

This is particularly important in cell culture research, where serum-containing media harbors significant IGFBP concentrations that would rapidly sequester native IGF-1 and attenuate its signaling