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GLP-1 Story Continues Here are the key figures since Q2 2024: Q2 2024: GLP-1 revenue: $12 million Total revenue: $325 million Share of GLP-1 revenue: 4 % Q3 2024: GLP-1 revenue: $55 million* Total revenue: $441 million Share of GLP-1 revenue: 12 % Q4 2024: GLP-1 revenue: $162 million* Total revenue: $488 million Share of GLP-1 revenue: 33 % Q1 2025: GLP-1 revenue: $ 230 million Total revenue: $596 million Share of GLP-1 revenue: 39 % Q2 2025: GLP-1 revenue: $190 million Total revenue: $545 million Share of GLP-1 revenue: 35 % * Estimate based on the $229M GLP-1 revenue for FY 2024 Revenue Momentum Stalls Amid GLP-1 Reliance Historically Hims has issued conservative guidance and then surpassed the top end of its range

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The FDA requires a CVOT for all antidiabetic agents per its 2008 guidance, and a GLP-1-class CVOT is standard for obesity agents following SELECT (semaglutide 2.4 mg, N=17,604) which showed a 20% reduction in MACE [11]

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Ubiquitin signalling in neurodegeneration: Mechanisms and therapeutic opportunities

We focused less on cost, more on value for the money