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The mean area under the concentrationtime curve (AUC 0-90 ), maximum plasma concentration (C max ), and time to maximum plasma concentration (T max ) values by dose at 30% CV are shown in Table 3

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MCMs were derived from murine macrophage cell line (RAW264.7 cells) by sequential hypotonic lysis, homogenizer extrusion, gradient centrifugation, and low-temperature sonication processes, following established literature protocols 31,32 (Fig