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GLP-1 and GIP receptor agonistsare unlikely to cause severe hypoglycemia unless combined with other medications for diabetes

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Another study revealed that gentamycin induced nephrotoxicity by over-producing of reactive oxygen species and free radicals and significantly increased serum NGAL, KIM-1 and cystatin-c whereas Irbesartan and other angiotensin II blockers reverse this effect and improve renal function through Modulation of oxidative stress and endogenous antioxidant Capacity [57]

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Even modest weight loss of 5-7% can significantly improve liver steatosis, whilst losses exceeding 10% may lead to improvements in inflammation and fibrosis

recent bleeding in the brain ( cerebrovascular bleeding )