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Novo Nordisk has faced relentless pressure in 2026 CagriSema's head-to-head failure against tirzepatide, the semaglutide patent expiration opening doors for generics in multiple markets, and the imminent arrival of Lilly's once-daily oral GLP-1 pill

, Morrone, L

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But semaglutide reduces cravings and your appetite, so youre more likely to incorporate it as a lifestyle rather than a short-term, quick fix

Both carry a boxed warning for thyroid C-cell tumor risk, based on animal studies, a critical consideration, as noted in Tirzepatide vs