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Potential new therapeutic target for alzheimers disease: Glucagon-like peptide-1

Most importantly, cardiovascular monitoring remains warranted despite favorable population-level profiles, as long-standing severe obesity can itself affect cardiac structure and function, and individual-level events are not precluded

Christensen reports advisory boards and speakers bureau for Novo Nordisk and speakers bureau for Eli Lilly

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doi: 10.1016/j.cmet.2018.03.001

In the pancreas, these agents enhance glucose-dependent insulin secretion while suppressing inappropriate glucagon release, improving glycemic control with a low risk of hypoglycemia when used alone (though this risk increases when combined with insulin or sulfonylureas)