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Dopamine is essential for reward, motivation, and focus, while norepinephrine plays a role in alertness and regulating responses to stress

Labeling adds a further challenge

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GLP-1 receptors in mesolimbic reward circuitry the nucleus accumbens, the ventral tegmental area are the presumed substrate for semaglutides anti-craving effects

They also have different effectiveness, dosing, and cost

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