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Proc Natl Acad Sci U S A (2012) 109(11):425762.10.1073/pnas.1119803109 144 GanYZhangYBuckelsAPatersonAJJiangJClemensTLet alIGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity

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Once active GLP-1 is secreted, the enzyme DPP-4 quickly cleaves the majority of the hormone 10 and the remaining active GLP-1 enters circulation

[10] It is plausible, though not yet proven specifically for retatrutide, that combined stimulation of GLP-1 and glucagon receptors could produce a more pronounced elevation in heart rate compared with single or dual agonists