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By focusing on how the body functions rather than just how it looks, this method represents a more advanced path toward lasting results.

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No formal PRISMA methodology, risk-of-bias assessment, or evidence grading system was applied, as the aim of this work was to provide a critical narrative synthesis of the current evidence rather than a systematic quantitative assessment

Prescribers may advise temporarily holding metformin-containing medicines around contrast imaging or serious illness, depending on the situation

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In 2024, it also gained FDA approval for a second use: reducing the risk of serious heart problems, such as heart attack and stroke, in adults with cardiovascular disease and obesity or overweight, and in 2025 gained approval for helping treat MASH