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And what I saw early on is that actually we can make a shift in our patient population very quickly

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Pro-inflammatory cytokines disrupt neurotransmitter metabolism through mechanisms such as inhibited tryptophan conversion to serotonin while driving microglial activation, thereby amplifying neuroinflammation (271)

Semaglutide starts at 0.25 mg weekly for four weeks before stepping to 0.5 mg, then escalates in 4- to 8-week intervals toward 2.4 mg [3]