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Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al

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This molecular pathway may be influenced by the level of daily physical activity, as a study using high-throughput sequencing found that physically fit individuals had higher fecal butyrate levels, better VO2 max values, more diverse gut microbiota, lower LPS biosynthesis, and consequently, less systemic inflammation [22, 44]

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Rats were acclimatized to a controlled environment of 22 1 C temperature and a 12-h light/dark cycle, with free access to food and water, for 2 weeks prior to the experiments